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How does zinc paste affect the skin?

Abstract of a scientific article on veterinary sciences, author of the scientific work – Fedota Natalya Viktorovna, Lukyanova Daria Aleksandrovna

The results of testing an ointment based on zinc oxide with the addition of silver microparticles, synthesized by employees of the North Caucasus Federal University, are presented. The ointment is part of a group of new pharmacological preparations for optimizing tissue regeneration processes in thermal burns. The experiments were performed on outbred white rats aged 60-80 days. with an average weight of 130-150 g. It has been established that in terms of the effectiveness of the bactericidal action, silver preparations are in many ways superior to other antibacterial drugs. Final and complete healing of burn wounds in rats with the use of an ointment containing zinc oxide and silver microparticles occurred by 16-18 days. When using Argosulfan and zinc ointments, healing occurred only on the 19-22nd day. i Nadoeli bannery? Vy vsegda mojete otklyuchit advertisement.

Similar topics of scientific papers in veterinary sciences, the author of the scientific work is Fedota Natalya Viktorovna, Lukyanova Daria Aleksandrovna

Results of treatment of victims with burns of the hands Histomorphological picture of the wound process when using an ointment based on nanoparticles in the treatment of wounds Possible areas for improving the results of medical care for victims with burns of the hands INFLUENCE OF THIOTRIAZOLINE OINTMENT WITH SILVER NANOPARTICLES ON THE CONTENT OF IL-1β AND TNF-α IN BLOOD SERUM AND LESION DURING EXPERIMENTAL THERMAL BURN The influence of an ionized silver preparation on the reparative regeneration of the skin and underlying tissues when modeling thermal and chemical burns in rats i Ne mojete nayti to, chto vam urgent? Poprobuyte servis podbora literatury.
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EFFECT OF OINTMENTS BASED ON SILVER AND ZINC ON SKIN REGENERATION OF SIMULATED THERMAL BURNS IN RATS

The results of testing the ointment based on zinc oxide mixed with silver microparticles, synthesized by the research workers of North-Caucasian Federal University, are submitted in the article. The above ointment is included in the group of pharmacological preparations intended to optimize the processes of tissue regeneration after thermal burns. The non-pedigree white rats aged 60-80 days, with 130-150 g mean weight were included in the experiments. It has been established that the silver preparations in terms of their bactericidal action are much more effective as compared with other anti-bactericidal preparations. The final and complete healing of burn wounds in rats treated with the above ointment, containing zinc and silver microparticles, occurred by the 16-18th day. The healing of wounds treated with Argosulfan ointment occurred only by the 19-22nd days.

Text of the scientific work on the topic “The influence of ointments based on silver and zinc on skin regeneration when modeling thermal burns”

The influence of ointments based on silver and zinc on skin regeneration when simulating thermal burns N.V. Fedota, Ph.D., D.A. Lukyanova, graduate student, Stavropol State Agrarian University An analysis of the Russian pharmaceutical market showed the presence of a fairly wide range of drugs used to treat thermal burns. However, most drugs are not universal, and the effect is far from optimal. This makes it advisable to search and develop perfect and innovative means that stimulate regenerative and reparative processes in tissues [1-3]. The presence of a large number of different sulfonamide drugs and antibiotics in no way reduces the importance of using drugs in the clinic that have natural antibacterial activity. Based on the literature analysis, we considered it appropriate to conduct research on the wound-healing effect of drugs based on zinc oxide and silver microparticles, studying their effect on the regeneration of damaged skin and underlying tissues. In terms of their effectiveness in killing bacteria, silver solutions are much more active than many antibacterial drugs. It is known that silver suppresses both gram-positive and gram-negative microflora, while preserving the natural microflora of the body. An important point is the fact that pathogenic microorganisms do not develop resistance to silver ions. The therapeutic effect of silver on the healing of trophic ulcers that develop due to impaired circulation of the lower extremities has been noted [3-6]. The effect of killing bacteria with silver preparations is very high, which has been confirmed by numerous experiments. Bacteria resistant to penicillin and biomycin are not resistant to silver and its preparations. For the treatment of animals, in particular in the pharmacotherapy of burns, frostbite, bedsores, trophic ulcers, silver preparations such as silver nitrate (lapis), protargol and collargol, Argosulfan, Dermazin are widely used [4-6]. In medicine, one of the components of anti-burn therapy, which has anti-inflammatory, drying, adsorbing, astringent and antiseptic effects, are zinc compounds, which are used externally in the form of powders, ointments, pastes, liniments. Zinc compounds are one of the components of a number of complex dermatological and cosmetic preparations, such as zinc ointment, Lassar paste, etc. Their pharmacological action is in the formation of albuminates and protein denaturation. When applied to the affected surface, the processes of exudation, inflammation and tissue irritation are reduced [3]. The goal of our research is to test new pharmacological drugs to optimize tissue regeneration processes in thermal burns. The subject of research is an ointment based on zinc oxide with the addition of silver microparticles, synthesized by employees of the North Caucasus Federal University. Materials and methods. The experiments were performed on outbred white rats aged 60-80 days. with an average weight of 130-150 g, n = 15. All animals were kept in the same conditions in the vivarium of the Faculty of Veterinary Medicine of the Stavropol State Agrarian University (in natural light, 1 air +20-22°C, humidity 55-60%), in plastic cages measuring 55 x 45 x 15 cm, on a standard food mode, with a bedding of sawdust. Animals were taken into the experiment after seven days of quarantine. The animals were divided into three groups. In I gr. the burn surface in rats was treated twice daily with Argosulfan ointment, in group II. – zinc ointment, III gr. – with the study drug in a similar regimen. Thermal burn modeling was carried out according to generally accepted methods. The area of ​​the burn wound was about 8-9% of the entire body surface. To calculate its values ​​in rats, we used the formula proposed by Mikha: where S is the surface of the body, cm2; W—animal body weight, kg; k is Mich’s constant (9,46). The study included studying the effect of a drug based on zinc and silver on reparative processes after a simulated burn. To do this, we recorded the dynamics of changes in the area of ​​the burn surface, the rate of tissue epithelization, and the nature of the zone of demorcification inflammation. Research results. As a result of the studies, it was found that in animals of group I. on the 5th day. experiment, the average wound area decreased by 27,6%, in group III. – by 48,2%, in II – by 12,1% (table, figure). On the 10th day. experiment, the scab was removed from the burn surface. A clean and pink bottom, located at the level of the edges of healthy skin, was observed only in animals of group III. In rats II gr. the bottom was deep, uneven, the scab was difficult to remove. Average wound area in animals in group III. decreased Area of ​​burn wounds due to the use of various drugs, cm2 Group Experiment period, days. 1st 3rd 5th 10th 14th I 2,53 2,32 1,83 1,1 0,7 II 2,55 2,38 2,24 1,68 1,25 III 2,54 1,82 1,31 0,5 0,2 Argosulfan I Zinc ointment Rice. – Changes in the area of ​​burn wounds due to the use of various drugs by – 80%, I gr. – by 56,5%, II gr. – by 34,1%. In animals II gr. There was a large area of ​​hyperemia around the wound. On the 14th day. experiment, area of ​​burn wounds in rats, group I. decreased by 72,3%, II gr. – by 50,5%, and III – by 92,1%. In animals III gr. area of ​​the burn wound on the 14th day. was less than in groups II and I, by 71,4 and 84,0% respectively. Final and complete healing of burn wounds in rats with the use of an ointment containing zinc oxide and silver microparticles occurred by 16-18 days, in animals of groups I and II. when using Argosulfan and zinc ointment – on days 19-22. accordingly, i.e. for 3-4 days. Later. Conclusions. As a result of the research, it was found that the new ointment based on zinc oxide and silver microparticles has pronounced wound-healing properties compared to well-known monopreparations. 1. Alekhina E.V., Orobets V.A. Determination of acute toxicity of a complex preparation based on silver nanoparticles // Management of functional systems of the body: collection. articles. Stavropol, 2010. pp. 44-44. 2. Belyaev V.A., Safonovskaya E.V., Degtyarenko A.V. and others. Toxicity of the disinfectant “Biopag-D” for mammals // Veterinary Bulletin. 2013. No. 66 (3). pp. 66-68. 3. Kochetygov N.I. Burn disease. L., 1973. 4. Fedota N.V. Technology for increasing the activity and extending the shelf life of tissue preparations // Bulletin of the Saratov State Agrarian University named after. N.I. Vavilova. 2012. No. 6. P. 42-43. 5. Fedota N.V., Belyaev V.A., Gorchakov E.V. Pharmaceutical chemistry: educational and methodological. allowance. Stavropol: AGRUS, 2013. P. 160. 6. Gilpin, DA Calculation of a new Meeh constant and experimental determination of burn // Proceedings of National Avian-Wind Power Planning Meeting. 1996. Vol. 22. No. 8. P. 607-611. Treatment and prevention of diaper dermatitis. Treatment of dermatitis, eczema, diaper rash, skin damage (minor thermal and sunburn, cuts, scratches). Composition: active substance: zinc oxide; 1 g ointment contains zinc oxide 0,1 g vspomogatelnye veshchestva: white soft paraffin. Medical form. Ointment 10%. Basic physical and chemical properties: ointment white or white with a yellow tint. The ointment should be homogeneous in appearance. Pharmacological group. Preparations with a softening and protective effect. ATX code D02A B. Pharmacological properties. Pharmacological. “Zinc ointment” has an astringent, adsorbent, antiseptic effect, and reduces the severity of exudative processes. When applied topically, it reduces the manifestations of inflammation and irritation of the skin, softens and dries it. Pharmacokinetics. When applied externally, “Zinc ointment” is practically not absorbed into the systemic circulation and does not exhibit a resorptive effect. Clinical characteristics. Indications. Treatment and prevention of diaper dermatitis. Treatment of dermatitis, eczema, diaper rash, skin damage (minor thermal and sunburn, cuts, scratches). Contraindications. Hypersensitivity to the components of the drug. Purulent-inflammatory diseases of the skin and adjacent tissues. Interaction with other drugs and other types of interactions. No interaction established. Features of application. The ointment is for external use only. Do not use for pustular skin diseases. Apply the ointment only to uninfected areas of the skin. Do not allow the ointment to come into contact with mucous membranes or eyes. If the ointment gets into your eyes, rinse them with plenty of running water and consult a doctor. If a child’s diaper rash does not disappear within 7 days of starting to use the drug, it is necessary to stop treatment and consult a doctor again. Use during pregnancy or breastfeeding. The use of the drug during pregnancy and lactation is possible only when the expected benefit to the mother outweighs the potential risk to the fetus or child. The ability to influence the reaction rate when driving vehicles or other mechanisms. The drug does not affect the ability to drive vehicles or operate machinery. Method of administration and dose. Diaper dermatitis in children For the purpose of prevention, apply the ointment to clean and dry skin (under diapers), especially before bedtime, to prevent skin irritation through prolonged contact with wet diapers. For therapeutic purposes, apply the ointment to the skin in a thin layer three times a day (if necessary, during each diaper change) at the first signs of hyperemia (redness of the skin), diaper rash or minor skin irritation. Dermatitis, eczema, thermal and sunburn, cuts, scratches, diaper rash The ointment is applied in a thin layer to the affected surface. If necessary, apply a gauze bandage. The duration of treatment is determined by the doctor depending on the nature and course of the disease. Children. The drug can be used in pediatric practice. Overdose. When applied topically, an overdose is unlikely. Accidental ingestion of large doses may cause stomach pain, nausea, vomiting, diarrhea, central nervous system stimulation and convulsions. Adverse reactions. Hypersensitivity reactions to the drug, including itching, hyperemia, rash, changes in the site of application of the ointment, peeling, pain, urticaria. Long-term use may cause skin irritation. Shelf life. 5 years. Storage conditions. Store in a place protected from light at a temperature not exceeding 25 ° C. Keep out of the reach of children. Packaging. 20 g in tubes. Vacation category. No recipe. Manufacturer/applicant. Location of the manufacturer and address of the place of its activities / location of the applicant. Ukraine, 46010, Ternopil, st. Factory, 4. Tel. / Fax: (0352) 521-444, www.ternopharm.com.ua Date of last revision. 23.10.18

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