Mineral Review

How many days does it take for bismuth to leave the body?

On the eve of the examination, food overload should be avoided.

Urine:
On the eve of the test, it is not recommended to eat vegetables and fruits that can change the color of urine (beets, carrots, cranberries, etc.), or take diuretics.

Collect the morning portion of urine excreted immediately after sleep. Before collecting urine, it is necessary to perform a thorough hygienic toilet of the external genitalia. When urinating for the first time in the morning, release a small amount of urine (the first 1-2 seconds) into the toilet, then collect the entire portion of urine in a clean container without interrupting urination. Pour approximately 50 ml of urine into a sterile plastic container with a screw cap. When collecting urine, it is advisable not to touch the container to your body. It is necessary to deliver the container with urine to the medical office as soon as possible from the moment the biomaterial is taken.

Women are not recommended to take a urine test during menstruation.

  • hair should be clean and thoroughly dried;
  • Perm without coloring and hair bleaching do not interfere with the analysis. It is recommended to analyze dyed hair two months after the dyeing procedure;
  • stop using medicated shampoos, anti-dandruff products, mousses, medicated balms and gels two weeks before submitting your hair for analysis. If you use drugs like Antisedin, you must stop using them three months before the test;
  • Wash your hands thoroughly before cutting hair. Latex gloves are not recommended because they are treated with talc, which may contaminate the hair sample. The tool for cutting hair (scissors or razor) must have clean cutting surfaces;
  • Carefully cut off the hair (do not pull it out!) in the immediate vicinity of the roots, in four to five places on the back of the head closer to the neck area. Leave the length of the cut hair 3-5 cm from the roots, and cut off the excess. If the hair is very short, then it must be cut in an amount that can fill a teaspoon;
  • Collect the cut hair into a bun 2–3 mm thick and place it in a small inner envelope. In the area of ​​the envelope where the root end of the strand is located, write “root”;
  • The inner small envelope along with the collected material and the completed order form must be placed in a large envelope.

In Moscow, you can undergo this study without queues or pre-registration. It is necessary to prepare for the procedure according to the algorithm described above.

The results will be sent to the patient’s email within 5 days after the procedure. They can also be found in your personal account on the DNAOM website. You will be able to receive printed results at the office where the test was taken.

When you take tests at DNAM offices, you become a participant in the cumulative discount loyalty program! For a total cost of research of 1000 rubles or more, the user receives a 3% discount from the second visit on the next day. The maximum discount is 10%, you can check it in your personal account.

Pharmacological group of the substance Bismuth tripotassium dicitrate

Nosological classification

  • K29.1 Other acute gastritis
  • K29.5 Chronic gastritis, unspecified

CAS code

pharmachologic effect

pharmachologic effectgastroprotective, antiulcer.

Pharmacology

Mechanism of action

Under the influence of gastric juice, insoluble compounds are formed from bismuth tripotassium dicitrate, which are deposited mainly on the ulcerated area and inhibit the activity of pepsin. Bismuth tripotassium dicitrate also protects the mucosa by stimulating the synthesis and secretion of endogenous PGs, thereby increasing the production of bicarbonate and mucin. In addition, tripotassium bismuthate dicitrate has antibacterial activity against Helicobacter pylori. The eradication of these bacteria is accompanied by an improvement in the histological picture and symptoms of peptic ulcer disease.

Pharmacodynamics

Tripotassium bismuthate dicitrate promotes the healing of a significant proportion of gastric and duodenal ulcers. Its antibacterial effect is associated with a lower incidence of ulcer recurrence in the first year after cessation of treatment compared to some other drugs.

Pharmacokinetics

Bismuth tripotassium dicitrate has a local effect. However, a small amount of bismuth is absorbed (less than 0,2% of the dose) during therapy.

Distribution

Bismuth is distributed predominantly in the kidneys. Only trace amounts may be found in other organs.

Biotransformation

Bismuth tripotassium dicitrate locally precipitates in the stomach under the action of gastric juice, forming insoluble compounds, presumably bismuth oxychloride and citrate.

The bulk of ingested bismuth is excreted in feces. The renal clearance of small amounts of absorbed bismuth is approximately 50 ml/min. At least a three-component model is required to describe bismuth excretion over time. T1/2 is 5–11 days.

Preclinical safety data

Single oral administration of bismuth did not increase mortality in rats at doses up to 2000 mg/kg. There were no significant changes associated with bismuth administration in clinical signs, body weight, food intake, hematology, clinical chemistry, urinalysis, organ weights, necropsy, or histopathologic findings in a 28-day repeated oral dose toxicity study. The level of no observed harmful effects of bismuth was determined to be 1000 mg/kg for males and females. No signs of hepatotoxicity were observed. There were also no histopathological changes in the bone marrow or lymphoid organs (thymus, spleen, lymph nodes).

The mutagenicity of bismuth cannot be assessed due to insufficient studies.

Evidence-based studies of the effect of bismuth citrate on male or female fertility and early embryonic development have not been conducted. Maternal toxicity was detected in rabbits. However, no adverse effects were observed on pre- or post-implantation loss, number of viable fetuses, or fetal development. Bismuth tripotassium dicitrate has not been evaluated for phototoxicity.

Application of the substance Bismuth tripotassium dicitrate

Stomach and duodenal ulcers; eradication Helicobacter pylori in combination with other drugs; gastritis associated with dyspepsia, eradication if necessary Helicobacter pylori.

Противопоказания

Hypersensitivity to the active substance; severe renal failure.

Application in pregnancy and lactation

There is insufficient data to assess the potential adverse effects of tripotassium bismuth dicitrate during pregnancy in women. To date, animal testing has shown no evidence of such effects. Due to the lack of data, the use of bismuth tripotassium dicitrate during pregnancy is not recommended.

There are insufficient data on the use of bismuth tripotassium dicitrate during lactation in women to evaluate its potential harmful effects during breastfeeding.

Side effects of the substance Bismuth tripotassium dicitrate

This side of the immune system: very rarely – anaphylactic reaction.

So strony JKT: very often – black stool; uncommon – nausea, vomiting, constipation, diarrhea.

So storony koji i podkojnyx tkaney: uncommon – rash, itching.

Interaction

You should not use other drugs, in particular antacids, or consume food or drinks, milk, fruit or fruit juices within half an hour before or after taking bismuth tripotassium dicitrate, as they may affect its effect.

Theoretically, it is possible to reduce the absorption of tetracyclines with simultaneous use.

Overdose

Symptoms: An acute, severe overdose can lead to the development of renal failure with a latent period of up to 10 days.

Treatment: a single exposure to a very high dose should be treated with gastric lavage followed by repeated administration of activated charcoal and osmotic laxatives. Typically, this will prevent bismuth absorption to the point that additional treatment is not required.

In both cases of acute and potentially chronic intoxication, to confirm the effect of bismuth, it is necessary to determine its concentration in the blood and urine. If symptoms are caused by acute or chronic bismuth overdose, chelation therapy with dimercaptosuccinic acid or dimercaptopropanesulfonic acid should be considered. If there are also signs of severe renal dysfunction, hemodialysis should be performed after chelation.

Dosing and Administration

Inside, swallowing whole, drinking enough water 2-4 times a day on an empty stomach (half an hour before meals or before bedtime), the course of treatment is from 4 to 8 weeks, the interval between courses of treatment using drugs containing bismuth should be at least 2 months For eradication Helicobacter pylori the choice of combination therapy and duration of treatment (from 7 to 14 days) should take into account individual tolerability and be carried out in accordance with regional requirements.

Use in children and adolescents is not recommended.

Safety measures

Long-term use of high doses of bismuth compounds is not recommended, because this may lead to the development of reversible encephalopathy. The likelihood of this event occurring is very low when bismuth tripotassium dicitrate is used as recommended.

Concomitant use of other bismuth-containing compounds is not recommended.

Impact on the ability to drive vehicles and operate machinery. There is no data on the effect of the use of bismuth tripotassium dicitrate on the ability to drive vehicles. In any case, the effect of bismuth tripotassium dicitrate on the ability to drive a car or operate machinery is unlikely.

Information sources

Product label, 2022.

Lobanova Elena Georgievna (pharmacologist, doctor of medical sciences, professor)
Experience: more than 29 years

Trade names with the active substance Bismuth tripotassium dicitrate

Tradename Price per package, rub.
Vicanol® Life from 712.00 to 712.00
Bismuth tripotassium dicitrate-VERTEX from 426.00 to 602.00
Vitridinol® from 822.00 to 822.00
De-Nol® from 928.00 to 1022.00
Novobismol® from 719.00 to 934.00
Ulcavis® from 245.00 to 861.00

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