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What are the contraindications for succinic acid?

When should you take tablets or do injections with succinic acid? How is succinic acid beneficial and harmful to the body? Roskachestvo expert, MD, nutritionist, cosmetologist Mariyat Mukhina tells.

What is succinic acid

Succinic acid, also known as butanedioic acid, is a weak organic acid with the chemical formula C4H6O4 or HOOC−CH2−CH2−COOH. Under standard conditions, it is a colorless, odorless crystalline substance, with a slightly acidic and easily recognizable salty-bitter taste, somewhat similar to citric acid. Historical data indicate that in the 17th century, succinic acid was first obtained by distilling amber. Therefore, salts and esters of succinic acid are called succinates, derived from the Latin word succinum, meaning “amber”. This substance is used to produce medicines and dietary supplements (dietary supplements), presented in the form of tablets, capsules, injection solutions, or packaged in sachets. The unique properties of succinic acid are used in cosmetic masks, scrubs, tooth powders, as well as in inhalation tinctures. This additive is used in animal feeds and plant fertilizers.

Benefits of succinic acid for the body

Succinic acid is necessary for the body for metabolism, for the absorption of oxygen by organs and tissues of the body and the production of ATP. Succinic acid is a key element in the processes of formation of substances that are actively involved in the development and renewal of cells and tissues, and, by the way, helps remove harmful substances from the body. It is not for nothing that it is recommended to take it for a hangover. The positive effect of succinic acid salts on brain function has the potential to significantly delay the manifestation of signs of aging and prevent negative changes in the brain associated with age. It is for this reason that this substance is recommended for use when the first signs of the development of pathological processes in the brain appear in elderly people. Mariyat Mukhina
Doctor of Medicine, nutritionist, cosmetologist This unique element is an effective guardian of the body’s cells, preventing the effects of negative environmental factors. Its antitoxic, antiviral and antihypoxic properties affect the body as a whole, providing reliable protection and promoting overall well-being. Usually the body produces succinic acid on its own and can direct it to the necessary “work front”. For example, to suppress the proliferation of malignant cells, reduce the production of histamine, regulate energy metabolism and restore the normal functioning of organs and tissues by stabilizing biochemical reactions. Let’s summarize. Succinic acid is:

  1. Powerful adaptogen. Helps improve the body’s adaptation to various conditions and increase overall endurance.
  2. Detox-nutrient that improves the removal of harmful substances from the body. Accelerates the process of alcohol processing, reducing its toxic effects on the body and the duration of the hangover syndrome.
  3. Energy tonic. Promotes intensive fat burning to produce energy. Increases performance and concentration.
  4. Metabolism activator. Improves metabolic processes, activates intracellular metabolism and cellular respiration, exhibiting an antihypoxic effect.
  5. Anti-age support component. Has pronounced antioxidant properties. Prevents premature aging of the skin and the whole body.
  6. Natural anti-stress factor. It has a neurotropic effect, improving the functioning of brain cells.

Benefits for the female body

In general, there is no difference for the male and female body. In both cases, butanedioic acid activates the immune system and improves the absorption of amino acids. It also enhances collagen production (stimulates neocollagenesis), which has a beneficial effect on the freshness of the face. Creams and injections with succinic acid enhance local skin immunity, prolonging youth.

Is it possible for children?

Is it possible to give a child succinic acid? Children can take succinic acid only as prescribed by a doctor. The metabolism of children is better than that of adults, and there is no need to stimulate it with drugs.

Is succinic acid useful during pregnancy and breastfeeding?

Succinic acid improves blood circulation and increases blood pressure. Therefore, during pregnancy it is prescribed if the expected benefit to the mother outweighs the potential risk to the fetus. What harm could it do to the expectant mother?

If a woman suffers from a gastric ulcer, then the formation of gastric juice may increase, which will cause an exacerbation.

If a woman suffered from hypertension, succinic acid is a powerful stimulator of blood flow and can provoke a hypertensive crisis.

Succinic acid is a powerful tonic that improves brain activity. Taking the drug after 18:00 causes activation of the sympathoadrenal system and insomnia.

During pregnancy and breastfeeding, it is definitely better to forget about cosmetic procedures, which are injections of drugs containing succinic acid, and indeed about any other injections except the most necessary ones.

Diseases for which the use of succinic acid is recommended

Succinic acid preparations are used in many areas of medicine. These are cardiology, neurology, endocrinology, toxicology and narcology, infectious diseases, pediatrics, and rehabilitation medicine. UC has been used in surgery, pulmonology, hematology, dermatology, obstetrics and gynecology. And all because succinate is directly involved in the processes of tissue respiration and oxidative phosphorylation in mitochondria.

In addition to antihypoxic and antioxidant effects, UC drugs have nootropic, anticonvulsant and anxiolytic effects.

The “sunstone” product is used for hypoxia, varicose veins, heart failure, as well as to strengthen the immune system and normalize the functioning of the pancreas. Its value is manifested in the prevention of age-related dementia and cognitive disorders, in increasing stress resistance under increased mental and physical stress.

YAC drugs are prescribed for chronic forms of coronary heart disease, especially when reconstructive surgery on the coronary arteries is impossible, and the reserves of standard therapy have been exhausted (A. V. Smirnov, O. B. Nesterova, R. V. Golubev. “Succinic acid and its use in medicine”).

Nutrition expert, nutritionist Mariyat Mukhina, emphasizes that this substance also has a positive effect during intoxication, including alcohol, and helps lower blood sugar levels.

Succinic acid is also effectively used for weight loss, activating processes that promote the breakdown of fat, notes Mariyat Muradalievna. – In this case, taking drugs with UC is enough not more than one tablet a day and no more than a month, so as not to provoke gastrointestinal diseases.

Is succinic acid harmful?

Since succinic acid stimulates blood circulation and increases blood pressure, drugs based on it, supplements with succinic acid are best not taken by hypertensive patients, people suffering from urolithiasis, people with glaucoma and, as mentioned above, pregnant and lactating women.

Also among the contraindications:

  • Individual intolerance to the therapeutic drug. Hypersensitivity to the components of succinic acid can cause a severe allergic reaction that requires hospitalization.
  • Angina pectoris.
  • Severe late gestosis.
  • Eye diseases, in particular glaucoma.
  • Impaired renal function.

When and how should you take succinic acid?

It is advisable not to take any medications without first consulting your doctor. If the doctor approves the use of succinic acid, the drugs are usually prescribed for a month, from 1/2 to 3 tablets per day.

Daily requirement for succinic acid

To determine the required amount of acid that should be received daily, you need to use the following formula: 0,03 g * body weight of the person for whom the calculation is being made. The resulting product will be called the daily norm of succinic acid.

A person weighing 60 kg needs 1,8 g of succinic acid per day.

If energy support is required, then one tablet per day is enough (200 mg of succinic acid per tablet). In this case, the maximum dosage is 400 mg, that is, two tablets. This is only 20% of the daily requirement. But no more is needed.

Remember, you should not take more than two tablets a day. And the course should not last for months.

Succinic acid is taken for a maximum of a month, then you need to take a break for two months, says Dr. Mukhina. – Succinic acid, if consumed excessively, is dangerous for the mucous membrane and can cause ulcer formation.

Succinic acid should be taken strictly after meals, preferably washed down with broth.

Time to take succinic acid

Better in the morning and afternoon. YAK excites the brain, activating mental activity, so do not drink it before bed (after 18:00), otherwise you risk not falling asleep for a long time.

The drug begins to act within 20 minutes after administration.

Do I need a doctor’s prescription?

In order to buy succinic acid in a pharmacy, you do not need a doctor’s prescription. But you should not self-medicate and prescribe this drug to yourself. To get started, consult your doctor. An exception can be made if you have a hangover: 1-3 tablets of succinic acid will mobilize the strength of your body and help remove toxins (again, if there are no contraindications).

But with a hangover, it’s not the pills that will have the greatest effect, but the droppers, adds Mariyat Mukhina.

Used in cosmetics

Preparations containing succinates and hyaluronic acid are used in cosmetology. Local intradermal injections of these drugs on the skin of the face and neck, hands or the whole body (if necessary) can have a rejuvenating effect; this redermalization procedure attracts moisture to the skin, making it more elastic.

Redermalization helps eliminate signs of aging (both age-related and photoaging), moisturize very dry skin, smoothes acne marks and wrinkles, evening out skin tone. Prepares the skin for peeling so that it can recover as quickly as possible. Succinic acid has many uses in cosmetology, but it is better to find out what is right for you in consultation with a specialist. In addition, injections usually have many contraindications, including the tendency of the skin to scar, acute illnesses, poor blood clotting, malignant tumors and much more. If there are no contraindications, procedures can be performed immediately after consultation.

How often do such procedures need to be performed to have an effect? They are done in a course, once a month, three procedures a year.

Against hair loss

The highlight of preparations with succinic acid (or succinate) is that the area of ​​application is not limited to the face, neck and décolleté. The drug is used for the scalp. Excellent results have been noted for hair loss and subsequent hair restoration in post-Covid syndrome.

In the periorbital zone, injection is possible even close to the ciliary margin. The drug not only prevents puffiness, but also eliminates it, and at the same time dark circles under the eyes. And this is not surprising, because succinic acid has excellent drainage properties.

As a result of the synergistic action of hyaluronate and succinate, the formation of collagen and other structural dermal components significantly increases, the hydro reserve increases, the density and elasticity of the skin increases, microcirculation and lymph outflow are normalized. This means that the specialist can be sure that the client is guaranteed long-term hydration, smoothing out wrinkles and increasing skin elasticity, evening out skin tone and giving it radiance.

Succinic acid is an excellent photoprotector

This means that this is exactly the biorevitalizant that is needed in the summer. And it is with this drug that you can start a course of summer biorevitalization.

You shouldn’t follow “rejuvenation tips” from the Internet: why can’t you make “masks” from UC tablets?

There are tips on the Internet for rejuvenation using succinic acid at home. For example, it is recommended to crush succinic acid tablets into powder and add to hand cream or mix with honey and apply to hands. Or make masks for rejuvenation by applying a paste of crushed tablets to your face.

Is it worth doing this? What could this lead to? Mariyat Mukhina warns against off-label procedures (from the English off-label, off – outside, label – label, instructions: this is the name for the use of medicines for indications not approved by state regulatory bodies, not mentioned in the instructions. – Ed. .).

If the “advice” concerns the use of succinic acid tablets for external rejuvenation of the skin of the face and body, then the benefits of succinic acid for the face and body are more than doubtful. These procedures can be very damaging to the skin. In addition to succinic acid, the tablets may contain microcrystalline cellulose; maltodextrin; anti-caking agent: talc; stabilizers: croscarmellose, fatty acids (stearic acid); anti-caking agent: amorphous silicon dioxide.

When rubbed into the skin, starch and talc form microcrystals that injure and, as it were, abrasively erase the protective top layer of the skin. Then succinic acid penetrates into the dermis and simply causes a burn.

When, instead of being used orally, tablets are crushed and applied to the face, mixed with water, honey or cream, these pseudo-procedures will not help rejuvenate. But they can lead to allergies, skin burns and even neoplasms, and can provoke carcinogenesis,” says Dr. Mukhina. – You can’t follow this advice.

Products that contain succinic acid

Among the products that contain succinic acid are fruits: citrus fruits (oranges, tangerines, grapefruits, lemons); gooseberry; grape; mango; apricots and plums; apples; cherries and sweet cherries. These are fermented milk products – kefir and yogurt. There is succinic acid in cheeses, baked goods made from rye flour, and brewer’s yeast. Oysters and aged wines have it. YAC is found in sugar cane, turnips and other plant foods.

What foods contain a lot of succinic acid? How much succinic acid is in products?

Although succinic acid is found in many foods, the amount varies. On average, 100 g of product can contain from several milligrams to one gram of succinic acid.

For example, oranges contain approximately 20-30 mg of succinic acid per 100 g of product, tangerines – about 10-20 mg, and grapefruits – approximately 30-40 mg. However, these numbers may vary depending on the size and variety of the fruit. Gooseberries contain succinic acid in an amount of about 10 mg per 100 g of product.

Let me remind you that the body is capable of producing UC on its own, so there is no need to constantly obtain it from food in large quantities,” Dr. Mukhina emphasized.

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Succinic acid is a popular additive in many pharmaceutical and cosmetic preparations. It is believed to speed up metabolism and support the nervous system. However, like any other supplement, succinic acid, if used incorrectly, may not have a completely beneficial effect on the functioning of the body. Lenta.ru found out what the benefits of succinic acid are, what harm it can cause, and how to properly use drugs based on this substance.

  • What is succinic acid?
  • Where is succinic acid used?
  • Benefits of succinic acid for the body
  • What side effects and contraindications does succinic acid have?

What is succinic acid?

Succinic acid, also known as butanedioic acid, is an organic compound that plays an important role in human metabolic processes and is considered a natural regulator of the body’s functioning. Externally, it appears as white crystals with a bitter-sour taste, reminiscent of citric acid.

Butanedioic acid was first obtained in the 17th century during the processing of natural amber. Then it turned out that it is also found in small quantities in some plants, vegetables, fruits and berries (rhubarb, beets, grapes, gooseberries), seafood (most of all in oysters), dairy products (cheese, natural yogurt) and wine. But despite this, today it is mined mainly by hydrogenation of maleic anhydrite.

succinic acid per day is produced by the human body

However, many people take it additionally in the form of dietary supplements – especially under high physical, psycho-emotional, intellectual stress and stress, in order to support the functioning of the nervous system.

Succinic acid is actively produced in human cells. A healthy body needs those succinates (natural salts and acids) that it synthesizes or absorbs from food. But due to the influence of stress, bad habits, and physical activity, tension appears in metabolic processes – the consumption of succinic acid increases, thereby causing its deficiency

Tatyana Borisova, physiotherapist, nutritionist at the Biogena clinic

Several centuries ago, immediately after the discovery of the substance, preparations based on succinic acid were used mainly for the treatment of rheumatic pain and chronic urethritis.

Where is succinic acid used?

Today, succinic acid is used in various fields: the food industry, cosmetology, pharmaceuticals and even agriculture.

It acts on plants in much the same way as vitamins on the human body, supporting all organs and systems. Acid improves soil properties, stimulates plant growth, helps them absorb nutrients from the ground, increases the germination of crops, increases the survival rate of seedlings and protects indoor flowers from wilting. However, when working with it, it is important to understand that it does not eliminate the need to use fertilizers and fertilizing – after all, the acid only works as an assistant for their absorption.

In the food industry, succinic acid is used as an acidity regulator – as an acidulant (additive E363)

Most often it can be found in wine, beer and vodka, dry drink concentrates and soups. Succinic acid is also used to produce resins and plastics. In pharmaceuticals, butanedioic acid is used to make medicines.

In what preparations is succinic acid used?

  • arsenic and mercury-containing drugs, quinolitine;
  • antidepressants;
  • means to strengthen the immune system, to improve the functioning of the nervous system, brain, heart, liver, kidneys;
  • preparations based on succinic acid that inhibit the development of inflammatory processes and cancer cells;
  • antidotes.

However, the use of succinic acid in medicine is not limited to this. It is part of various dietary supplements: weight loss products, to reduce blood sugar levels or the intensity of menopausal symptoms, tablets for stress, high physical, psycho-emotional, and intellectual stress.

All such preparations based on succinic acid affect metabolic processes, because the acid acts as a natural regulator of the body’s functioning

Benefits of succinic acid for the body

In the body, succinic acid is involved in the production of adenosine triphosphate (ATP), the source of energy for biochemical processes. Therefore, it is vitally important for humans.

Butanedioic acid promotes the breakdown of glucose through the aerobic pathway and the synthesis of ATP, which leads to better energy metabolism. That is why in preparations based on succinic acid it acts as a means to accelerate metabolic processes. Simply put, succinic acid is associated with the production of energy spent on life.

In the human body, succinic acid is found in the form of anions and salts called succinates. They ensure the absorption of diatomic oxygen by the cell, and therefore normalize the breakdown of substances and metabolic processes.

Nutritionist Maria Menshikova, in an interview with Lenta.ru, noted that succinic acid is necessary for all human organs and systems.

What benefits does succinic acid bring to the body:

  • Strengthens the nervous system and mental health: succinic acid helps reduce stress, anxiety and depression, also improve sleep and reduce fatigue;
  • accelerates metabolic processes: succinic acid – its anions and salts called succinates – promotes metabolic processes and can be useful for weight loss. These are natural regulators of the body’s functioning;
  • improves immunity: succinic acid is used to protect the immune system and protect the body from infections;
  • strengthens the heart: succinic acid has a beneficial effect on the cardiovascular system and can help lower cholesterol levels.

Succinic acid is used for the prevention and treatment of diseases of the cardiovascular system. According to research, succinic acid salts have positive evidence for vascular lesions due to the participation of succinates in the oxidation of fatty acids. This reduces the risk of cholesterol formation on the walls of blood vessels. It also prevents the loss of calcium in cells

Tatyana Borisova, physiotherapist, nutritionist

In addition, butanedioic acid contains many antioxidants and therefore has an anti-inflammatory effect. Preparations based on succinic acid are often used to treat chronic inflammatory diseases of the joints and tonsillitis.

Anions and salts of this substance provide the human body with energy and oxygen. In this regard, butanedioic acid is classified as an antihypoxant – it helps improve cellular respiration, reduces the effect of free radicals on the body, thereby slowing down aging.

Therefore, butanedioic acid is also used in cosmetology: it is often found in face creams, masks and lotions to prevent wrinkles. It is believed that an allergic reaction to products with succinic acid rarely occurs, because it is produced by the body, but such cases also happen.

What side effects and contraindications does succinic acid have?

At the same time, drugs based on succinic acid have their own contraindications and side effects. Nutritionist Maria Menshikova listed some of them.

Contraindications and side effects of succinic acid:

  • Allergies: Some people may experience an allergic reaction to succinic acid;
  • danger for children: babies under one year old may not have enough enzymes to convert salts called succinates into carbon dioxide and water, which can lead to side effects;
  • nausea and vomiting: they can be caused by excess butanedioic acid in the body;
  • influence on the effect of medications: succinic acid may affect the effectiveness of some medications, so if taken simultaneously, consult a doctor.

In general, succinic acid, when used correctly in accordance with the recommendations of a specialist, can be beneficial for health

Maria Menshikova nutritionist at Teledoctor24

In order to calculate the daily rate of succinic acid in the body, you can use a simple formula: multiply body weight by 0,03 grams. However, you can take butanedioic acid only with the permission of your doctor and strictly adhere to the dosage specified in the instructions.

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