Why does bismuth cause stomach pain?

Numerous studies have proven the pathogenic role of the bacterium Helicobacter pylori in the development of gastritis and peptic ulcers of the stomach and duodenum. Epidemiological studies conducted in many countries of the world, including Russia, have proven the widespread distribution of this microorganism. Today, therapy for peptic ulcer disease is primarily associated with the diagnosis of Helicobacter bacteria. When a pathogen is identified, drugs directed against Helicobacter pylori must be included in the complex treatment regimen. The pharmacist talks about the drug Bismuth tripotassium dicitrate: composition, mechanism of action, indications, contraindications and side effects. Compares the product with its analogue Ulcavis.

Radar station

• belongs to the pharmacotherapeutic group “Antiulcer, antiseptic intestinal and astringent”;
• dispensed from pharmacies without a doctor’s prescription;
• included in the List of Vital and Essential Drugs (vital and essential drugs) of the Russian Federation and the pharmacy Minimum range of drugs.

Composition

The composition of the drug Bismuth tripotassium dicitrate includes the active substance of the same name, which is also contained in other well-known drugs: De-Nol, Escape, Ulcavis. Under the trade name Bismuth tripotassium dicitrate, the product is produced by Russian pharmaceutical companies Avexima, Vertex, Ozon, etc.

Bismuth tripotassium dicitrate is a film-coated tablet containing 120 mg of the active substance in terms of bismuth oxide. The dosage of tablets is the same for all manufacturers.

Mechanism of action

Let’s look at how the substance bismuth tripotassium dicitrate (BTD) acts in the body and answer the question of whether it is an antibiotic or not.

VTD has a pronounced antiulcer, anti-inflammatory and astringent effect, as well as a bactericidal effect against Helicobacter pylori. Once in the stomach, the substance forms a protective film on the surface of ulcers and erosions on the mucous membrane. At the same time, the drug stimulates the production of protective prostaglandin E, which increases mucus secretion and reduces the concentration of hydrochloric acid and pepsin activity. This facilitates the healing of ulcerative lesions.

By nature and structure, VTD is not an antibiotic, but has an antimicrobial effect. It inhibits the activity of enzymes in bacterial cells and destroys their structure. Thus, the drug Bismuth tripotassium dicitrate has a dual mechanism of action: it destroys Helicobacter pylori and restores mucous membranes.

Bismuth tripotassium dicitrate-Vertex: from what?

• exacerbation of gastric and duodenal ulcers, including those associated with Helicobacter pylori;
• exacerbation of chronic gastritis and gastroduodenitis, including those associated with Helicobacter pylori;
• IBS – irritable bowel syndrome;
• functional dyspepsia not associated with gastrointestinal diseases.

Противопоказания

• hypersensitivity to any components of the tablets;
• pregnancy, lactation;
• taking other bismuth-containing drugs;
• chronic renal and liver failure;
• age to 4 years.

Side effects

• very often: black stool;
• uncommon: nausea, vomiting, diarrhea or constipation; skin rash, itching;
• very rarely: anaphylactic reactions; with long-term treatment in high doses – encephalopathy due to the accumulation of bismuth in the central nervous system.

Which is better: Ulcavis or Bismuth tripotassium dicitrate?

Ulcavis is a complete analogue of Bismuth tripotassium dicitrate: they have the same active ingredients, release form, dosage, indications, etc. The average cost of treatment is also at the same level.

The differences between Ulcavis and Bismuth tripotassium dicitrate lie only in the manufacturers of the active substances: for the drug Ulcavis, the Slovenian company KRKA uses raw materials from Germany, and domestic companies from Russia and China. The patient can choose any of them taking into account his own preferences.

Summary

• According to the Register of Medicines, bismuth tripotassium dicitrate belongs to the pharmacotherapeutic group “Antiulcer, antiseptic intestinal and astringent”.
• The composition of the medicine Bismuth tripotassium dicitrate includes the active substance of the same name.
• The drug Bismuth tripotassium dicitrate has a dual mechanism of action: it destroys Helicobacter pylori and restores mucous membranes.
• The drug has few contraindications: age under 4 years, pregnancy, lactation, hypersensitivity, taking other drugs with bismuth, renal and liver failure.
• Adverse reactions of the drug are few and reversible, that is, they disappear after discontinuation of the drug.
• The differences between Ulcavis and Bismuth tripotassium dicitrate lie only in the manufacturers of the active substances: for the drug Ulcavis, the Slovenian company KRKA uses raw materials from Germany, and domestic companies from Russia and China. The patient can choose any of them taking into account his own preferences.

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Still have questions? Ask them in the comments below – our experts will answer you. There you can share your experience with other readers of Megatips.

I took it from the pharmacy during the next exacerbation of gastritis instead of De-nol, and I realized the difference between the original and a copy of the drug. Next time, only De-nol!

Gennady Arkhipov
March 25 2022

Bismuth tripotassium dicitrate tablets 120 mg 112 pcs.

The pharmacy offered me this analogue instead of an expensive imported product. I didn’t like the pills; they gave me constant nausea and problems with bowel movements. I don’t recommend it.

Sergeev Arkady
December 7 2021

Bismuth tripotassium dicitrate-Vertex tablets 120 mg 28 pcs.

I was worried about stomach problems: heartburn, cramps, loose stools. A doctor I know advised me to take a course of this medicine. I took 4 tablets a day. After a couple of weeks, the symptoms began to gradually subside

Vladimir Zubov
October 29 2021

Bismuth tripotassium dicitrate-Vertex tablets 120 mg 112 pcs.

My stomach began to hurt badly, after tests they found Helicobacter, I took antibiotics and Bismuth tripotassium dicitrate from Vertex, the latest examination showed that there was no bacteria.

Ivan Alexandrov
April 14 2021

Bismuth tripotassium dicitrate-Vertex tablets 120 mg 56 pcs.

I’ve been taking it for a long time, about 7 weeks. It’s the last one left, and I’ve already forgotten how the symptoms of gastritis feel.

Anfisa Vorontsova
December 10 2020

Bismuth tripotassium dicitrate-Vertex tablets 120 mg 112 pcs.

I first bought this drug as an analogue to imported De-nol. I liked it: both for the price and for the action. It relieves heartburn well and quickly treats exacerbation of gastritis.

23 September 2020

Bismuth tripotassium dicitrate tablets 120 mg 112 pcs.

I periodically buy the drug, it helps well with inflammation of the duodenum, it has been tested more than once or twice, I have chronic gastroduodenitis.

Bismuth tripotassium dicitrate-Vertex tablets 120 mg 112 pcs.

Nice big packaging that lasts a long time. In principle, the price is also ok. The intestines are restored perfectly.

Svyatoslav Sokolov
July 13 2020

Bismuth tripotassium dicitrate tablets 120 mg 112 pcs.

The doctor prescribed a complex treatment with De-nol and Nexium for reflux esophagitis, and bought tripotassium Bismuth at the pharmacy. still half the price of De-nol. I drank the entire course and forgot about it due to heartburn and stomach pain.

Victoria Doronina
11 May 2020

Bismuth tripotassium dicitrate tablets 120 mg 60 pcs.

I complained of weakness and drowsiness, had all the tests done, and was told that I had anemia, due to gastritis, which prevents me from absorbing iron. Bismuth tripotassium dicitrate was prescribed. I tolerated the pills easily. After the follow-up examination, everything was fine.

Ivan Bogdanov
January 29 2020

Bismuth tripotassium dicitrate tablets 120 mg 120 pcs.

With my ulcer, I no longer knew what medicine to take, and finally I found Bismuth tripotassium dicitrate. The name is complicated, but the drug is simple and easy to use. And most importantly it works and eliminates unnecessary bacteria.

Konstantin Vadimovich Ivanov
January 11 2020

Bismuth tripotassium dicitrate tablets 120 mg 56 pcs.

A gastroenterologist prescribed these tablets to me in combination with other drugs for the treatment of gastritis. I can’t fully evaluate the effects of this medicine, since I also take others, but overall I feel better.

Mikhail Voronov
20 September 2019

Bismuth tripotassium dicitrate tablets 120 mg 56 pcs.

They eliminated diarrhea, namely irritable bowel syndrome, but got closed bowel syndrome, that is, complete constipation. It somehow had a strong effect on me.

Morozov A. D.
August 12 2019

Bismuth tripotassium dicitrate-Vertex tablets 120 mg 112 pcs.

Thanks to De-nol, and sometimes its substitutes – Tripotassium Bismuth, I manage without surgery for now, I take them during an exacerbation, they help heal the stomach ulcer.

Anna Nikitina
March 11 2019

Bismuth tripotassium dicitrate tablets 120 mg 112 pcs.

I bought myself a large package because I have gastritis and it gets worse from time to time. But he didn’t help me on his own. I had to add other medications as well.

Alena Lapina
March 8 2019

Bismuth tripotassium dicitrate-Vertex tablets 120 mg 56 pcs.

The last couple of months I have been suffering from stomach problems. All pills only temporarily relieve symptoms, but do not cure. I was advised this drug with bismuth. I drank it according to the scheme every day before meals. After 3 weeks it hasn’t gotten much better.

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Source of information about descriptions of medicines and dietary supplements: Register of Medicines of Russia-RLS®